Neural Cell Adhesion Molecule L1

A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

Also Known As:

L1 Cell Adhesion Molecule; CALL Protein; CamL1 Gene Product; Cell Adhesion Molecule L1; Cell Surface Glycoprotein L1; F11 Glycoprotein; L1CAM; NGF-Inducible Glycoprotein; NILE Glycoprotein; NILE Protein; Nerve Growth Factor-Inducible Large External Glycoprotein; Neural Adhesion Molecule L1; Glycoprotein, NGF-Inducible; Glycoprotein, NILE; NGF Inducible Glycoprotein; Nerve Growth Factor Inducible Large External Glycoprotein

Carbohydrates: 22516
- Glycoconjugates: 1370
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Cell Adhesion Molecules: 4912
        Neuronal Cell Adhesion Molecules: 9
        Neural Cell Adhesion Molecules: 1100
        Neural Cell Adhesion Molecule L1: 606
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Cell Adhesion Molecules: 4912
        Neuronal Cell Adhesion Molecules: 9
        Neural Cell Adhesion Molecules: 1100
        Neural Cell Adhesion Molecule L1: 606
  - Membrane Proteins: 10262
    - Membrane Glycoproteins: 2277
      - Cell Adhesion Molecules: 4912
        Neuronal Cell Adhesion Molecules: 9
        Neural Cell Adhesion Molecules: 1100
        Neural Cell Adhesion Molecule L1: 606
Biological Factors: 2560
- Antigens: 145631
  - Surface Antigens: 5857
    - Cell Adhesion Molecules: 4912
      - Neuronal Cell Adhesion Molecules: 9
        Neural Cell Adhesion Molecules: 1100
        Neural Cell Adhesion Molecule L1: 606

J R Thomas Selected Research

J R Thomas Research Topics

Disease

Drug/Important Bio-Agent (IBA)